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PLoS One 12:e0175732

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6.1 Mechanism of action of food bioactives on gut microbiota and inflammation Food bioactives such as polyphenols, flavonoids, and other bioactives demonstrate potential in ameliorating metabolic syndrome through multifaceted mechanisms (Afolabi et al., 2022

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Notably, this occurred in the absence of improved insulin sensitivity, neuroinflammation, brain mTORC1 signaling, or activation of brain autophagy all physiological and molecular changes that have been hypothesized to explain the ability of CR to slow the development or promote the clearance of A plaques