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Preservation of Lean Body Mass : Unlike traditional calorie-restriction models that can cause muscle loss, AOD-9604 research indicates a preservation of lean muscle tissue while reducing total body fat

Acknowledgments The authors are grateful to Eric Fritzsche, Arvid Lauber and Ewa Schneider for their technical assistance

[Abstract]2024 Jul 23:S1931-3128(24)00254-3

Curcumin exerts context-specific autophagy regulation through dual mechanisms: At moderate concentrations (2025 M), it promotes cytoprotective autophagy via inhibition of the mechanistic target of rapamycin (mTOR)-AKT axis (Zhao et al., 2016), evidenced by decreased p-AKT, p-mTOR, and p-P70S6K expression, coupled with increased microtubule-associated protein 1A/1B-light chain 3- II/microtubule-associated protein 1A/1B-light chain 3-I (LC3-II/LC3-I) conversion

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Human efficacy data are limited