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2016;15:S28.Google Scholar Patriquin, H, Lenaerts, C, Smith, L, et al

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Blocking these molecules, the inhibitory costimulatory interactions between T cells and tumor cells are also inhibited, resulting in positive costimulation and strong cell activation, which allows both the T cells to kill tumor cells and the uncontrolled T cell activation to disrupt immune tolerance like taking the brakes off the immune system, causing various inflammatory autoimmune myopathies (41)