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When managing patients taking opioid analgesics, particularly those who have been treated for an extended period of time, and/or with high doses for chronic pain, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper

Bolton WD, Rice DC, Goodyear A, Correa AM, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Pisters K, Roth JA, Swisher SG , Vaporciyan AA, Walsh GL, Weaver J, Rhines L

Compared to healthy states, their subgingival microbiota displays dysbiosis, characterised by increased pathogenic bacteria and reduced beneficial bacteria

Some variations in liming effects on soil biota were due to differences in duration of liming, liming material used and site-specific environmental characteristics

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Boyi Gan and colleagues defined disulfidptosis in 2023 as high SLC7A11 expression and NADPH depletion, resulting in the suppression of cystine/cysteine conversion under conditions of glucose starvation, which leads to disulfide bond accumulation, disulfide stress, and collapse of the cytoskeleton