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Accordingly, it has issued new advice to check vitamin B12 serum levels in patients being treated with metformin who have symptoms suggestive of vitamin B12 deficiency.[] The proposed mechanisms to explain metformin-induced vitamin B12 deficiency among patients with T2DM include alterations in small bowel motility, which stimulates bacterial overgrowth and consequential vitamin B12 deficiency, competitive inhibition or inactivation of vitamin B12 absorption, alterations in IF levels, and interaction with the cubulin endocytic receptor

Studies have found that supplementation with B12 can help to regulate normal sleep-wake patterns

Monitoring of cardiac function is necessary in symptomatic patients

Retrieved 21 April 2020

Research reveals both the potential and limits of fat-dissolving injection treatments for belly fat and abdominal areas

Daily oral GLP-1 receptor agonist orforglipron for adults with obesity