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Osteonecrosis: When injected into a joint, cortisone shots can cause osteonecrosis or the death of bone tissue

The prevalence of CAN among diabetes patients ranges from 20 to 60%

Dosing Protocol & Reconstitution Typically supplied as lyophilized powder for laboratory use

Insufficient dietary intake To prevent deficiency, oral cyanocobalamin supplementation once daily 20-50 mcg or 50-150 mcg is most commonly recommended.448 In some countries, methyl- and adenosylcobalamin-containing preparations are available

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Both drugs have FDA-approved labels with detailed prescribing information, boxed warnings where applicable, and post-market surveillance infrastructure