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This finding suggested that butyrate may have systemic effects that extend beyond direct contact with the local intestinal mucosa, impacting regions of the gut that are not in direct contact with the compound

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While high doses administered over a short duration can induce symptoms such as lethargy, decreased food consumption, and weight loss in these animals, no significant mortality has been observed within specific dosage limits (Mihailovi et al., 2013)

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During a 6-day culture period, the dimeric macrocycles at a concentration of 50 nM continuously promoted cell proliferation with comparable efficacy to hHGF at a concentration of 1.3 nM (Fig