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These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity

Mechanistic studies showed that GPX4 expression and ferrous iron were increased in 5-FU and AZ628-derived CRC persister cells, residual subcutaneous transplantation tumors, and colorectal cancer patients undergoing neoadjuvant chemoradiotherapy

Furthermore, targeting the metabolism of liver cancer cells can potentially improve T cell antitumor immunity

10.1136/heartjnl-2020-316780 46 RooneyM

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The current study suggests that the main intensification of agricultural activities started in the La Tne period and continued during the Roman period