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Therefore, these limitations made it necessary the use of polymeric NPs as more effective THA delivery carriers compared with free drugs, including Methoxypoly (ethylene glycol)-Polycaprolactone (mPEG-PCL) NPs in rat brain (Sathesh Kumar and Felix Joe, 2017) or poly(n-butyl cyanoacrylate) (PBCA) NPs coated with polysorbate 80 (aka Tween 80, T80) in mouse brain (Wilson et al., 2008b)

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