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Histone acetylation and depression The first evidence of histone acetylations role in depression came from studies showing that HDAC inhibitors (HDACi), used alone or with antidepressants, enhanced antidepressant responses in animal models 139,140,141

Knockdown of either of the two enzymes catalyzing GSH biosynthesis, glutamatecysteine ligase catalytic subunit (GCLC) and glutathione synthetase (GSS) also showed synthetic lethality with high MYCN state (Fig

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In particular, SFN improved antioxidant enzyme activities including SOD, CAT, and GPx, and also relieved the changes of inflammatory factors

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