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While polygenic risk scores (PRS) address part of this architecture by aggregating validated risk alleles from GWAS, the proposed workflow further considers the potential cumulative burden of variants typically deemed benign, aiming to bridge the gap between population-level risk estimation and individualized interpretation (Torkamani et al., 2018)

(2007) Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model

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An important regulator of the cysteine supply from astrocytes to neurons could also be the prion protein (PrP)