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Oxidative Stress and Chronic Inflammation in the Elderly Oxidative stress is an important contributing factor for several chronic diseases attributed to aging, such as atherosclerosis and related cardiac disorders, cancer, neurodegeneration, immunologic disorders, and the aging process itself (, H 2 O 2 , and OH are known as reactive oxygen species (ROS) and they are continuously being produced in vivo under aerobic conditions

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In C2C12 myotubes and skeletal muscle from obese mice, capsaicin upregulates sarco/endoplasmic reticulum Ca 2+ -ATPases (SERCA1/2) and ryanodine receptors (RYR1/2), thereby activating ATP-consuming Ca 2+ futile cycles that recycle Ca 2+ across the sarcoplasmic reticulum and dissipate energy as heat (13)