human glutathione synthetase kda total weight Inborn errors in the metabolism of | Orphanet Journal of Rare Diseases Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases

Aconitase, as well as other FeS cluster-containing dehydratases, are sensitive to both reactive oxygen species (ROS), including superoxide (O 2 - ) and hydrogen peroxide (H 2 O 2 ), and the production of the reactive nitrogen species (RNS) peroxynitrite (ONOO ) [[71], [72], [73]]

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Furthermore, IS and IAA, as typical AHR ligands, can bind to cytoplasmic AHR, and the IS/AHR complex translocates to the nucleus, where it binds to AHR nuclear translocation via heat shock protein 90 exchange and serves as a transcriptional activator by binding to specific xenobiotic response elements in promoter regions of enzymes that generate ROS [96]

Huang P, Jiang Q, Yu P, Yang L, Mao L (2013) Alkaline post-treatment of Cd(II)glutathione coordination polymers: toward green synthesis of water-soluble and cytocompatible CdS quantum dots with tunable optical properties

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