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A decreased SAM/SAH ratio, reflecting impairment, is associated with an increased risk of atherosclerosis in the elderly and may serve as a diagnostic biomarker [135, 136]

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On the other hand, A2 astrocytes, are considered neuroprotective and increase the expression of neurotrophic factors such as BDNF, glial cell line-derived neurotrophic factor (GDNF) and NGF, which promote synaptic growth and repair, as well as neuronal survival (Lam et al., 2019)