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The compounds that were effective across multiple models were further tested as single agents and in combination with a clinically relevant protocol mimicking COJEC 12 , the five-chemotherapy cocktail (cisplatin, vincristine, carboplatin, etoposide and cyclophosphamide) that is the first line of action to treat HR-NB patients set by the International Society of Pediatric OncologyEuropean Neuroblastoma (SIOPEN) 6

doi: 10.1016/j.molliq.2015.05.023

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unnamed protein product Gene Aliases: GST5

Mitochondrial dysfunction Mitochondria are indispensable organelles responsible for ATP production and coordination of calcium homeostasis, hormone synthesis, signal transduction, and apoptotic regulation 79,80

A 5 mg vial reconstituted with bacteriostatic water yields about 5.0 mg/mL