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Meanwhile, side effects increase more linearly with dose

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Patients on GLP-1 therapy often remain in a low-grade inflammatory state during the active weight loss phase, which can slow the very tissue remodelling that would otherwise benefit from reduced adiposity

The antioxidant power of the intestine was compromised due to inhibition of key antioxidant enzymes and decreased reduced glutathione levels which led to impaired free radical quenching and metal-reducing ability

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For comparison, zinc gluconate was used