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Chen Y, Wang Y, Chen J, Chen X, Cao W, Chen S, et al

In addition, research has demonstrated that specific inflammatory genes, including IL-1, IL-6, and TNF-, are prominently expressed in endothelial cells, fibroblasts, and macrophages in older populations with POP

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The hypomethylated CpG sequence in mtDNA binds specifically to the N-terminal part of the C-shaped leucine-rich repeat region of TLR9, mediating TLR9 activation (170, 171)

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

Lipoyl (octanoyl) transferase 2 catalyzes the transfer of the octanoyl moiety from ACP to a conserved lysine in the H protein of the glycine cleavage complex (see Biological Activities and Figure 3)