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This narrative review integrates biochemical, preclinical, and clinical data to map age-dependent changes in the serine/glycine, glutamine/glutamate, arginine/citrulline, cysteine/trans-sulfuration, and alanine cycles, examines their impact on osteogenesis and mucosal healing, and evaluates nutritional or pharmacological strategies to restore NEAA sufficiency

Simultaneously, several meta-analyses and guideline panels highlight that many claimed indications are supported only by low- to moderate-quality evidence, with significant heterogeneity between trials and frequent failure of some strains or formulations to demonstrate superiority over placebo in rigorous, well-controlled studies (2, 3)

Healthy growth and activity of immune cells depends on the availability of GSH

Oxidative stress, exacerbated following burn injury, drives the generation of pro-inflammatory mediators and the activation of microglia

The route of administration thus plays a pivotal role in the design of nanozymes for the treatment or monitoring of IBD (Fig

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