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This is a nuanced concern worth explaining carefully rather than dismissing outright, since it is one of the more frequently searched safety questions

[47] found that exosomes from NP cells (NP-exos) could successfully induce BMSCs to differentiate into NP cells, while exosomes from BMSCs (BMSC-exos) could promote the expression of NP cell-related genes and increase ECM production, thereby achieving the effect of IVD self-repair

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Biochim Biophys Acta (2000) 1488:16781

ELISA analysis of culture supernatants demonstrated that CMH@lip@TCeO 2 and CMH@lip@Res reduced the secretion of IL-1, IL-6, and TNF- relative to CMH@lip