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Xu, 2012)

2022;9(26):e2105885

The direct downstream targets of mTORC1 are ribosomal S6 kinase (p70S6K) and eukaryotic initiation factor 4Ebinding proteins (4EBP) which regulate protein translation, cell size and cell cycle progression 7,8

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To facilitate fatty acid synthesis, mitochondrial citrate is transported across the inner mitochondrial membrane into the cytosol through the citrate carrier (CIC or SLC25A1)

The NEJM-published GHRH trial in HIV lipodystrophy demonstrated 15% VAT reduction with Tesamorelin monotherapy, while subcutaneous abdominal fat decreased by only 1.2%