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Risk-adapted preemptive tocilizumab to prevent severe cytokine release syndrome after CTL019 for pediatric B-cell acute lymphoblastic leukemia: a prospective clinical trial

Many research protocols include monitoring or cycling strategies to maintain effectiveness and reduce potential metabolic or hormonal changes over time

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The invention also features receptor-specific antibodies which do not prevent ligand binding but prevent receptor activation

Front Immunol (2020) 11:66

Toxicol Appl Pharmacol 204:329342 Sun X, Shih AY, Johannssen HC, Erb H, Li P, Murphy TH (2006) Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface