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The prediction of future conversion to MCI over 15 years is unlikely to be explained by undiagnosed cognitive impairment, placing changes detected by these aging models early in the causal chain of cognitive decline and neurodegenerative disease

Additionally, biomarkers that indicate nutritional status, such as omega-3 indices, vitamin D levels, or microbiome composition, are reported inconsistently, which makes it difficult to replicate findings and conduct meta-analyses [123]

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Table 2 provides a summary of metabolites that are associated with the growth of vaginal microbes that have been shown to harbor antimicrobial resistance genes

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f , ABTS antioxidant assay (see Methods) for the proportion of ABTS radical quenched by supernatant isolated from the indicated strains after 72 h incubation in l-asparagine minimal medium (lacking l-DOPA)