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To date, few radiosensitising drugs have been approved for use clinically ( in vitro and ex vivo models of oesophageal adenocarcinoma ( Metformin is a clinically approved drug used for the management of type II diabetes ( This study demonstrates, through real-time live cell metabolic profiling and transcriptomic profiling, that metformin significantly alters energy metabolism in both in vitro and ex vivo models of rectal adenocarcinoma and importantly, radiosensitises radioresistant rectal cancer cells to clinically-relevant doses of X-ray radiation

Journal of Physiology and Pharmacology, 60 Suppl 7, 115122

When taken in oral, capsule or liquid form, glutathione takes time to be broken down or absorbed into the blood

Interestingly, excess NAC that is not immediately utilized for glutathione synthesis or chelation is converted into Krebs cycle intermediates

Espinosa et al

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice