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RSL3 suppresses viability in thyroid cancer cell lines To determine whether GPX4 inhibition affects tumor cell viability, we treated PTC cells with various concentrations of RSL3 and performed a cellular viability assay

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Further alterations in intracellular redox balance driven by lower GSH availability induce cell death and enhance T2 signature protein expression We previously demonstrated that 15LO1-PEBP1 complex activation consistently upregulates the expression of T2-signature gene/protein expression, including MUC5AC, periostin (POSTN), and CCL26 (6, 10, 14)