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Also it occurs at an activated carbon atom, that is next to sp , sp2 carbons: Oxidative Phase-I involving cytochrome P-450 enzymes: Aromatic hydroxylation: Oxidative Phase-I involving cytochrome P-450 enzymes: Alkene epoxidation: Glutathione conjugation For electrophilic drugs and metabolites: Glutathione conjugation Toxicity of aromatic compounds came from the formation of arene oxide during the metabolism that will be attacked by endogenous nucleophile such as proteins, DNA or RNA

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DON impacts the mucus layer composition by downregulating the expression of the gene coding for MUC2, as shown in a trial with human goblet cells (Pinton et al., 2015)

9 Another statistical analysis of 21 studies found that bariatric surgery resulted in decreases in hirsutism, menstrual irregularity, infertility, type 2 diabetes, high blood pressure, and depression