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Safety assessments included treatment-emergent adverse events (AEs), vital signs (BP and HR), bodyweight, physical examinations and laboratory parameters

doi: 10.1371/journal.pbio.2006203 17 FengSTangDWangYLiXBaoHTangCet al

the NF-kB pathway) independent of ligand engagement (121123)

Induced cultivations were kept on separate incubator from uninduced ones to avoid any effect of the highly volatile cyclohexanone

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Further research has demonstrated that this dysregulation of the negative feedback mechanism plays a vital role in PTSD, potentially being a key factor causing the persistence of chronic stress states (Sriram et al., 2012)