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The cross-talks between the progression of MetSys and prevalence of HCC have been widely investigated (220, 221)

*Correspondence: Yongzhi Shan, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Notably, even minor trauma can lead to BBB disruption (124)

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Nutrients , 12 (1), 217