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the most common were dry mouth and insomnia. Astrup et al., The Lancet Who Should Avoid Tesofensine Individuals with uncontrolled hypertension or cardiovascular disease Anyone on SSRIs, SNRIs, or MAO inhibitors (risk of serotonin syndrome) Those with a history of severe anxiety, panic disorder, or arrhythmias Pregnant or breastfeeding women (due to lack of safety data) Best Practices for Safety Start at 0.25 mg/day and gradually titrate Avoid stacking with caffeine , yohimbine , or stim-heavy pre-workouts Monitor blood pressure, heart rate, and sleep quality Discontinue use if side effects worsen or persist beyond the adaptation period (710 days) Although Tesofensine has a relatively clean side effect profile at moderate doses, its still a powerful central agent

doi: 10.1371/journal.pone.0103022 37 DengQHeBLiuXYueJYingHPanYet al

SYNCHRONIZE is the name of survodutides Phase 3 obesity program, part of a broader set of confirmatory trials that also includes the LIVERAGE MASH and liver-cirrhosis outcome studies and a large cardiovascular-safety trial (SYNCHRONIZE-CVOT)

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He is also President-Elect of the World Obesity Federation