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Owing to its interaction with distinct autophagy receptors, GPX4 has been demonstrated to be degraded following treatment with inducers of ferritin deposition or excessive copper, thereby instigating ferroptosis (159)

Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, et al

Furthermore, human Grx1 reacts twenty times faster with GSH than with L-cysteinylglycine or L-cysteine, revealing that the preference for GSH also depends on its -glutamyl moiety 19

Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: Preliminary findings

PMID: 11028671

Together, these results demonstrate that NADPH is the limiting reducing agent in glucose deprived cancer cells