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Results depend on the type and severity of the injury, dosing protocol, and individual response

STZ-induced diabetic rats had significantly fewer autophagic vacuoles and an accumulation of autophagy substrates (103)

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For instance, SAR441255designed with balanced activity across all three receptorsshowed some promising early efficacy for glycaemic control in a phase 1 single-dose study and was generally well tolerated [65], however, no further trials have been reported since 2019

However, N-terminal modifications, such as N-acetylation, D-norleucine substitution, or replacement with -aminobutyric acid (GABA), dramatically elongated the peptides half-lives