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Tomosugi N, Yamamoto S, Takeuchi M, Yonekura H, Ishigaki Y, Numata N

Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes

Supports neurological and cardiovascular health

One study covered in the review found that a topical containing Syn-Ake resulted in a 52% reduction in wrinkle size after 28 days of use.34 (As an interesting side note, you may have noticed that Syn-Ake kind of looks or sounds like the word snake. This is because the synthetic peptide Syn-Ake is an analog of a natural one called Waglerin-1, which is derived from the venom of the Southeast Asian temple viper.)34 As with Allies of Skin, much of the research behind the ingredients in The Ordinarys product is positive

Discovered in 1977 (Schoenenberger)

No peer-reviewed human RCT has yet validated a subcutaneous dose in people as of 2026 [5][6]