glutathione intake and cancer Human cancer-associated fibroblasts enhance levels antagonize drug-induced prostate cell death A study shows that the

HIGH GT EXPRESSION AND INTRATUMOR DRUG ACTIVATION The high expression of GT within aggressive and drug-resistant tumors implies that GSH-conjugated prodrugs, activated at the cell surface by GT, should be particularly effective against GT-positive tumors

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Importantly, none of the peptides with additional acidic residues showed off-target effects, even when peptides contained two (e.g., the peptides in Fig

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eds.), pp 2159