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Genetical evidence from key studies confirms that eliminating GPX4 expression via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L

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To further improve our understanding of which cysteines in GLRX react with GSSG, we carried out Induced Fit Docking (IFD) of GSSG to the GLRX model at the proximity of each cysteine