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For example, key studies on SHH MB utilized PTCH1 heterozygous mice (PTCH1 +/ ), which develop tumors at low penetrance (~20%) following loss of the wild-type PTCH1 allele (122)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Ding H., Wang X., Wang H., Zhu L., Wang Q., Jia Y., Wei W., Zhou C., Wu H., Ding K

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