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the two entities are conjugated by non-specific or specific protein- protein interaction, by covalent bonding, by non-covalent bonding, by coordinating chemical bonding, by chemical synthesis, either directly or via a (non)cleavable spacers, linkers or components of nanocontainers, or by recombinant technologies

The botanical drugs exhibit unique advantages due to their multi-target properties

J Biosci Bioeng 126:715722 Gallagher L, Owens RA, Dolan SK, OKeeffe G, Schrettl M, Kavanagh K, Jones GW, Doyle S (2012) The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis

In contrast, selenium-containing enzymes have selenocysteine as their active sites

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