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10.1038/ki.2010.377 61 HondaT.KabashimaK

2023) and UDP-glucuronosyltransferases (UGTs) yield pCG (Rong et al

1.5 Effects on laboratory mammals and in vitro test systems 1,2-Dibromoethane is acutely toxic to animals (oral LD 50 for rats of 146-417 mg/kg body weight, inhalation LC 50 for rats of 3080 mg/m 3 after a 2-h exposure, mortality observed following dermal application of 210 mg/kg to rabbits)

Oxidative stress refers to a pathological state in which excessive reactive oxygen species (ROS) are produced in the body or cells, or the function of the antioxidant system is impaired, leading to ROS accumulation and oxidative damage

Graphic abstract Access this article Data availability The data supporting the findings of this study are available from the corresponding authors upon reasonable request