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NAC also maintains mitochondrial redox homeostasis by activating the SIRT3-SOD2-GPX4 signaling pathway, thus reducing the ferroptosis rate in the context of DN

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Hypomethylation activates drug resistance genes Global hypomethylation (compared with cisplatin-sensitive HGSC cells) and local hypomethylation at the promoters of drug-resistant genes act synergistically