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Heffernan 2001a Mouse studies using chronic osmotic pump delivery showed AOD-9604 increased fat oxidation and plasma glycerol (a lipolysis marker) to a degree comparable with full-length hGH, without inducing hyperglycaemia or reducing insulin secretion

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In some cases, this applies to reduced calorie intake

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This suggests that Treg consumption is a key additional mechanism of action of these mAbs ( Figure 2 It was found that patients with at least a partial response to Daratumumab showed higher CD38 expression on MM cells ( in vitro