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By injecting melanoma cells into CD38/ mice, the function of CD38 could be studied and was found to be involved in (1) resistance to cell death, (2) tumor vascularization through a reduction in CD34, (3) recruitment of CAFs and (4) metastatic properties [50]

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Figure 3 Defense Responses in F 1 Hybrids of SA-Deficient and GSH Overproducer Tobaccos We also used F 1 hybrids from crosses between SA-deficient and GSH overproducer tobacco lines to explore how different endogenous SA levels affect in planta GSH accumulation and GSH-related defense reactions in response to TMV infection

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