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& Ilundin, A

145 This approach generally alters the gene expression of astrocytesan abundant glial cell type in the area of degenerationto convert them into neurons as a means for localized neuronal replacement

Another associated protein, nerve growth factor 1-A binding protein-2 (NAB2), which acts as a co-activator for EGR-1, has also been implicated

10.1136/bmj.m4087 39

PMID: 7710773 Biagioni C, Favilli F, Catarzi S, Marcucci T, Fazi M, Tonelli F, Vincenzini MT, Iantomasi T

Crossroads between melatonin and insulin Insulin, a hormone primarily synthesized by pancreatic -cells, has demonstrated notable efficacy in counteracting processes implicated in AD pathology upon reaching the brain [33]