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Description

Using whole-cell patch-clamp electrophysiology and micro-fluorescence Ca 2+ measurement of rat brain slices, study has demonstrated that the inhibition of hyperpolarization-activated current (Ih) determines the synaptic excitability of DA neurons

This large concentration difference means that there is an insurmountable concentration gradient that prevents extracellular glutathione from entering cells

A programme of phase 3 trials with retatrutide (TRIUMPH) is ongoing with an aim to assess the safety and efficacy of retatrutide in different populations living with obesity (OSA, T2D, established cardiovascular disease, osteoarthritis)