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[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Hollestein V, Poelmans G, Forde NJ, et al

PEG terminal hydroxyl groups have poor activity and must be activated with an activator to covalently modify proteins under mild conditions in vivo

In pancreatic cancer, danthron, sourced from Rheum palmatum, was seen to block autophagy, a protective process activated by DOX, thereby increasing DOX cytotoxicity and facilitating apoptosis