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HEK293T cells overexpressing Flag-GCLC were treated with class I and II HDAC inhibitor Vorinostat (SAHA) or class III inhibitor nicotiamide (NAM)

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Pre-treatment of human primary chondrocytes with alogliptin for 24 h (25 and 50 M) prevented the degradation of type II collagen and aggrecan dose-dependently