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When chronic diseases such as rheumatoid arthritis, CKD, cancer, or infections affect the production of red cells or the red cell maturation process called erythropoiesis, and lead to ways the body metabolizes iron through hepcidin-mediated processes getting out of control

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In the United States, where the vaccine rollout has been bumpy and winter storms over the past week have hampered some states' ability to administer shots, similar questions have emerged

Clinical indications include deficiency due to inadequate diet or malabsorption, drug-induced deficiency (for example, from long-term isoniazid or oral contraceptives), and certain inborn errors of metabolism (such as pyridoxine-dependent seizures or sideroblastic anemia)