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Activation of the canonical pathway has been classically associated with inflammation, while activation of the non-canonical pathway regulates cell development and organogenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Kang, H

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10.1016/j.tig.2012.09.005 196 MougeotJ.-L

This effect was evidenced by improved uptake of soluble antigens, elevated expression of genes encoding IL-6, TNF-, iNOS, and IL-1, and a marked increase in nitric oxide production (223, 224)