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Clinical and prognostic significance of HIF-1 in glioma patients: a meta-analysis

Canon, J

Morris HR, Spillantini MG, Sue CM, Williams-Gray CH

Because TG2 activity is highly associated with cellular redox status and alterations in the bidirectional flux of cellular thiol modulate TG2 activity, regulation of thiol flux in cells probably affects the TG2-mediated aggregation of the GST tag and its interaction with cellular proteins

In vitro and preclinical studies demonstrate that inhibiting key regulators (e.g., GPX4) effectively induces ferroptosis, reducing GBM cell viability and tumor growth [11]