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Long-term hyperglycemia damages multiple organs, including the kidneys, cardiovascular system, nerves, bones, and eyes, ultimately resulting in severe complications (5)

NAD levels may also decline due to chronic stress, drinking alcohol, environmental toxins and certain medications

There are in vitro observations that copper ions can inhibit the enzyme under specific laboratory conditions, but extrapolating this to a clinically meaningful, finasteride-like local DHT blockade on a human scalp is not supported by controlled human data

Oxidative stress and vascular disease

In addition, factors including ageing, poor diet, smoking, excessive alcohol consumption, chronic disease, and certain medications may disrupt normal methylation patterns

Moreover, in vivo fertilization and in vitro embryo culture experiments showed that uridine supplementation significantly improved fertilization and blastocyst formation rates in aged mice (Fig