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Primary antibodies, including CD206 antibody (Lot: YA798, MCE, USA) and iNOS antibody (Lot: HY-P80725, MCE, USA), were applied, followed by incubation with secondary antibodies, specifically goat anti-rabbit IgG (H+L) highly cross-adsorbed secondary antibody conjugated with Alexa Fluor 488 (Lot: A-11034, Thermo Fisher, USA)

Systemic Side Effects: Sermorelin is generally well tolerated, and because it triggers endogenous hormone release, systemic side effects tend to be mild for most patients

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and small-molecule drugs such as Janus kinase (JAK) inhibitors and sphingosine-1-phosphate (S1P) modulators

GH and testosterone have well-documented additive effects on body composition testosterone drives muscle protein synthesis through androgen receptor activation, while GH promotes lipolysis, collagen synthesis, and tissue repair through separate pathways