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On the other hand, these systems have the disadvantage that they can lead to drug deposits in certain areas of the body where they were administered

Insulin sensitivity changes: Prolonged high doses may affect insulin signaling

A linear gradient was applied from 2 to 70% mobile phase A over 20 min, followed by an 8-min equilibration step at initial gradient conditions

Disadvantages: Magnesium stearate has been criticized as it could inhibit the absorption of active ingredients in high quantities

Nevertheless, not having normative values for such a distal nerve and the absence of response expected in the majority of the patients with CIPN makes results in amplitude necessary to be interpreted in relation to those obtained proximally at sural nerve in the same patient

doi: 10.1212/WNL.21.11.1097 51 HuttenlocherP