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The constraint is storage: unopened lyophilised vials must be kept at 20C, which most home freezers maintain, but freezer space and organisation matter

This allows the medicine to go into the fatty tissue

It might also predict who is likely to develop the disease

Long-term sleep disturbance can affect energy levels, mood, and daily functioning

Peer review Peer review information Nature Communications thanks Nicolas Rouhier and Mirko Zaffagnini for their contribution to the peer review of this work